General Information

  • ID:  hor001156
  • Uniprot ID:  Q5ENY8
  • Protein name:  Neuropeptide AF36
  • Gene name:  AFP-12
  • Organism:  Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ascaris (genus), Ascarididae (family), Ascaridoidea (superfamily), Ascaridomorpha (infraorder), Spirurina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  VPSAADMMIRF
  • Length:  11
  • Propeptide:  MFSLKAIVMIALVVICTFCISESRRFHDDDFSRQFLFRGIDEPLKNYMRLREARILSKRVPSAADMMIRFGKRSFIEQDME
  • Signal peptide:  MFSLKAIVMIALVVICTFCISES
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q5ENY8-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001156_AF2.pdbhor001156_ESM.pdb

Physical Information

Mass: 141605 Formula: C54H88N14O15S2
Absent amino acids: CEGHKLNQTWY Common amino acids: AM
pI: 6.34 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 5
Hydrophobicity: 77.27 Boman Index: -678
Half-Life: 100 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 80
Instability Index: 3377.27 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21524146
  • Title:  Discovery of Neuropeptides in the Nematode Ascaris Suum by Database Mining and Tandem Mass Spectrometry